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In general, you can take over-the-counter (OTC) famotidine (Pepcid AC, Zantac 360) at any time of the day or night to help treat heartburn symptoms. OTC famotidine is available as a tablet, chewable tablet, or capsule. If your vet has recommended a famotidine product for your pet, a good starting point is Pepcid 20mg. Alot of people including myself, the prescription for Prilosec is cheaper than OTC but yes, same ingredients, same dose. Jane Top Reply Quote Post Reply. What is the difference between Pepcid and over-the-counter famotidine? Prescription Pepcid comes as a tablet (20 mg or 40 mg) or a liquid to take orally. Doses of prescription Pepcid depend on the condition being treated. Over-the-counter famotidine (Pepcid AC) is used to treat heartburn, and prescription famotidine (Pepcid) treats heartburn as well as stomach ulcers and gastroesophageal reflux disease (GERD). Read on to learn more about this shortage and what to do if you are taking this drug Although they work more slowly than antacids they provide relief for a longer period of time. Is Prevacid still available by presciption? The over the counter PPI’s are Tagamet HB, Pepcid AC, Axid, and Zantac. Pepcid products are widely available over the counter at pharmacies. These drugs effectively treat about ½ the patients with GERD. They take about 1 hour to start working effectively. Good for you for being a wise consumer shopper! A headache is the most common side more Prescription only.