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FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis Side Effects off Singulair Overall, Singular is a safe medicine, but side effects may occur. While the dose of inhaled corticosteroid may be reduced progressively under clinical guidance, Singulair needs to not be abruptly alternatived to inhaled or dental corticosteroids. SINGULAIR administered once daily had a safety profile consistent with that observed in patients with seasonal allergic rhinitis and similar to that of placebo. Montelukast is the generic form of the brand name drug Singulair. Doctors prescribe Singulair on a long-term. It reduces congestion in your nose and also cuts down on sneezing, itching, and eye. Timely by Time Cap Labs- Allergy Pills with Diphenhydramine 25 MG - 365 Count - Compared to Benadryl - Antihistamine Allergy Relief Tablets for Hay Fever, Runny Nose, Sneezing, Common Cold Discomfort. 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